Immunological mechanism of Panax ginseng for promoting antipyretic effects of Baihu Decoction by network pharmacology / 中草药

ABSTRACT

Qi-fen fever is a syndrome of Qi-fen syndrome in defensive qi nutrient blood syndrome differentiation. Baihu Decoction is a classic prescription of cooling Qi-fen, but when yang brightness heat at qi aspect is too exuberance to hurt human healthy qi and body fluid, Baihu with Ginseng Decoction will be used for treatment. In order to explore the mechanism of antipyretic effects of Baihu with Ginseng Decoction, this paper applied the network pharmacology method on the basis of summarizing the effects of ginseng on the natural immune system and the relationship between fever and the natural immune system. Firstly, 22 chemically active components of ginseng and their corresponding targets were screened by TCMSP database under limited conditions, and HPO database was used to search for fever-related disease targets. Secondly, the "ginseng-target-fever" network was constructed by STRING database corresponding to ginseng chemical active ingredients target and fever-related disease targets, and Cytoscape software was used to visualize the above network and obtained 18 key nodes according to the relevant characteristic parameters. Finally, The GATHER database platform was applied for the enrichment analysis of the gene function of key nodes. According to the network construction and topological calculation, it suggests that ginseng could activate the natural immune system by regulating MyD88-dependent or MyD88-independent Toll-like receptor signaling pathway to promote the antipyretic effects of Baihu Decoction.