Analysis of inorganic elements in Shexiang Baoxin Pills by ICP-MS / 中草药

ABSTRACT

Objective To establish a method for the simultaneous analysis of 26 trace elements in Shexiang Baoxin Pills (SBP), including Li, Na, Mg, Al, Ca, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, As, Se, Sr, Mo, Cd, Sb, Ba, Hg, Tl, Pb, and Bi. Methods The sample of SBP was digested by microwave with concentrated nitric acid, calibrated by internal standard elements, such as Ge and In, with bush branches and leaves as the controlled reference standard, and inlet into ICP-MS to analyze the contents of 26 inorganic elements. Results The detection limits and quantification limits of 26 elements were in the range of 0.010—2.987 μg/L and 0.035—10.000 μg/L. The 15 trace elements showed the good linearity in the selected concentration ranges (r ≥ 0.999 4), with the average recovery from 79.88% to 105.76%, while their RSD was below 4.55%. In the 12 batches of samples, the quantities of Ca, Mg, Na, and Fe were higher than 1.000 mg/g. The quantities of Mn, Cu, Zn, Al, and Ga were also relatively high, while the amount of Sb, Hg, Tl, and Bi was relatively low, which was below 0.050 μg/g. Conclusion The method is simple, rapid, and accurate, and can be used for the quality control of trace elements and heavy metals in SBP.