Chemical constituents from roots of Veratrilla baillonii / 中草药

ABSTRACT

Objective To study the chemical constituents from the roots of Veratrilla baillonii. Methods Compounds were purified by normal and reversed column chromatographic techniques, and isolated by high performance liquid chromatography. Their structures were identified on the basis of spectral data including MS and NMR. Results Twenty-four compounds (including 10 xanthone glycosides, 8 xanthones, and 6 iridoids) were isolated from the ethyl acetate extracts of the roots of V. baillonii. They were identified as 1-hydroxy-2,3,4-trimethoxyxanthone-7-O-β-D-glucopyranoside (1), tripteroside (2), 1-hydroxy-2,7-dimethoxyxanthone-3-O-β-D- glucopyranoside (3), 1-hydroxy-3,4-dimethoxyxanthone-7-O-β-D-glucopyranoside (4), secamonoide B (5), tetrasweroside A (6), veratriloside B (7), 2,3,4,5-tetramethoxyxanthone-1-O-β-D-glucopyranoxyl-(1→6)-β-D-glucopyranoside (8), 2,3,4,7-tetra- methoxyxanthone-1-O-β-D-xylopyranoxyl-(1→6)-β-D-glucopyranoside (9), 2,3,5-trimethoxy-xanthone-1-O-β-D-xylopyranoxyl- (1→6)-β-D-glucopyranoside (10), 1,3-dihydroxy-4,7-dimethoxyxanthone (11), 1,7-dihydroxy-2,3,4-trimethoxyxanthone (12), 1,7- dihydroxy-3,4-dimethoxyxanthone (13), 1,7-dihydroxy-3-methoxyxanthone (14), 1-hydroxy-2,3,4,5-tetramethoxyxanthone (15), 1-hydroxy-2,3,4,7-tetramethoxyxanthone (16), 1-hydroxy-2,3,5-trimethoxyxanthone (17), 1-hydroxy-2,3,7-trimethoxyxanthone (18), sweroside (19), gentiopicrin (20), swertiamarin (21), deacetylcentapicrin (22), amaronitidin (23), and amarogentin (24). Conclusion Compound 1 is a new compound named 2-methoveratriloside, and compounds 2, 3, 5, 6, 8, 10-12, 14, and 22-24 are isolated from the Veratrilla genus for the first time.