The immunohistochemical study on Ki-67 Expression in epithelial ovarian carcinomas / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 1288-1294, 2008.
Artigo
em Coreano
| WPRIM
| ID: wpr-85240
ABSTRACT
OBJECTIVE:
The study was to evaluate the biological significance of Ki-67 expression in common epithelial ovarian carcinomas. We investigated the correlation between Ki-67 expression and clinicopathological parameters.METHODS:
One hundred patients with epithelial ovarian carcinomas stage I-IV treated at Department of Obstertrics and Gynecology, Korea University Hospital from January 1994 to December 2004 were used as study group. We determined expression of Ki-67 by immunohistochemistry using MIB-1 monoclonal antibody reactivity.RESULTS:
Ki-67 overexpression was higher in high stage (III-IV) than low stage (I-II) (P<0.013). Ki-67 overexpression was higher in serous cystadenocarcinoma (76.3%) than mucinous cystadenocarcinoma (53.6%), endometrioid carcinoma (54.5%) and clear cell carcinoma (58.3%) but it was not statistically significant (P<0.191). Ki-67 expression was higher in high grade but it was not statistically significant (P<0.096). Ki-67 overexpression was not correlated with serum CA-125 level (P<0.172). Overall survival revealed significant survival difference between patients whose tumor showed Ki-67 overexpressions compared with remaining patients.CONCLUSIONS:
Ki-67 overexpressions was a poor prognostic indicator in epithelial ovarian carcinomas.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ovário
/
Imuno-Histoquímica
/
Anticorpos Antinucleares
/
Cistadenocarcinoma Seroso
/
Cistadenocarcinoma Mucinoso
/
Carcinoma Endometrioide
/
Antígeno Ki-67
/
Ginecologia
/
Coreia (Geográfico)
/
Anticorpos Monoclonais
Tipo de estudo:
Estudo prognóstico
Limite:
Feminino
/
Humanos
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
2008
Tipo de documento:
Artigo
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