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The immunohistochemical study on Ki-67 Expression in epithelial ovarian carcinomas / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology ; : 1288-1294, 2008.
Artigo em Coreano | WPRIM | ID: wpr-85240
ABSTRACT

OBJECTIVE:

The study was to evaluate the biological significance of Ki-67 expression in common epithelial ovarian carcinomas. We investigated the correlation between Ki-67 expression and clinicopathological parameters.

METHODS:

One hundred patients with epithelial ovarian carcinomas stage I-IV treated at Department of Obstertrics and Gynecology, Korea University Hospital from January 1994 to December 2004 were used as study group. We determined expression of Ki-67 by immunohistochemistry using MIB-1 monoclonal antibody reactivity.

RESULTS:

Ki-67 overexpression was higher in high stage (III-IV) than low stage (I-II) (P<0.013). Ki-67 overexpression was higher in serous cystadenocarcinoma (76.3%) than mucinous cystadenocarcinoma (53.6%), endometrioid carcinoma (54.5%) and clear cell carcinoma (58.3%) but it was not statistically significant (P<0.191). Ki-67 expression was higher in high grade but it was not statistically significant (P<0.096). Ki-67 overexpression was not correlated with serum CA-125 level (P<0.172). Overall survival revealed significant survival difference between patients whose tumor showed Ki-67 overexpressions compared with remaining patients.

CONCLUSIONS:

Ki-67 overexpressions was a poor prognostic indicator in epithelial ovarian carcinomas.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Ovário / Imuno-Histoquímica / Anticorpos Antinucleares / Cistadenocarcinoma Seroso / Cistadenocarcinoma Mucinoso / Carcinoma Endometrioide / Antígeno Ki-67 / Ginecologia / Coreia (Geográfico) / Anticorpos Monoclonais Tipo de estudo: Estudo prognóstico Limite: Feminino / Humanos País/Região como assunto: Ásia Idioma: Coreano Revista: Korean Journal of Obstetrics and Gynecology Ano de publicação: 2008 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Ovário / Imuno-Histoquímica / Anticorpos Antinucleares / Cistadenocarcinoma Seroso / Cistadenocarcinoma Mucinoso / Carcinoma Endometrioide / Antígeno Ki-67 / Ginecologia / Coreia (Geográfico) / Anticorpos Monoclonais Tipo de estudo: Estudo prognóstico Limite: Feminino / Humanos País/Região como assunto: Ásia Idioma: Coreano Revista: Korean Journal of Obstetrics and Gynecology Ano de publicação: 2008 Tipo de documento: Artigo