Study of action characteristics and comparative advantage of Liujing Toutong Tablets about analgesia / 中草药

ABSTRACT

Objective To observe the action characteristics and comparative advantage of Liujing Toutong Tablets (LTT) about analgesia compared with Zhengtian Pills through different analgesic pharmacodynamic model, experimental migraine model and qi stagnation and blood stasis model. Methods Analgesic effect of LTT on thermal stimulation and chemical stimulation through hot plate test and writhing test caused by acetic acid were observed. Experimental migraine model was induced by nitroglycerin, effect of LTT on the latency and times of scratching head response of migraine model rats were observed, and levels of NO, NOS, and β-EP in serum of migraine model rats were detected. The qi stagnation and blood stasis model was prepared by sc epinephrine hydrochloride combined with ice-water bath, and effect of LTT on cerebral blood velocity and hemorheology of qi stagnation and blood stasis model rats was observed. Results LTT could significantly prolong the latency of hot plate test and decrease writhing times caused by acetic acid in mice. LTT could significantly prolong the latency and decrease the times of scratching head response of migraine model rats, LTT could significantly decrease the level of NO and NOS, increase β-EP obviously in serum of migraine model rats. Also LTT could significantly increase the cerebral blood velocity and decrease blood viscosity as well as plasma viscosity of qi stagnation and blood stasis model rats. Conclusion LTT has significant analgesia effect with characteristics of working early and lasting long on central pain, inflammatory pain and experimental migraine model, also has significant activating blood and dissolving stasis effect on qi stagnation and blood stasis model. The analgesia effect of LTT is equal to Zhengtian Pills, but LTT works early and has multi-target compared with Zhengtian Pills.