Diterpenoid alkaloids in roots of Aconitum hemsleyanum var. circinatum / 中草药

ABSTRACT

Objective To study the chemical constituents in the roots of Aconitum hemsleyanum var. circinatum. Methods The constituents were isolated and purified by silica gel chromatography from the roots of Aconitum hemsleyanum var. circinatum, and the structures were identified by spectral analysis (1H-NMR, 13C-NMR, and MS). Results Seventeen compounds were isolated from Aconitum hemsleyanum var. circinatum and characterized as sachaconitine (1), 8-O-methylsachaconitine (2), liljestrandisine (3), talatisamine (4), chasmannine (5), 8-O-methyltalatisamine (6), 14-O-acetyltalatisamine (7), 8-deacetyl-yunaconitine (8), crassicautine (9), crassicaudine (10), crassicauline A (11), vilmorianine C (12), vilmorianine A (13), yunaconitine (14), transconitine B (15), kongboendine (16), and franchetine (17). Conclusion Seventeen compounds are isolated from Aconitum hemsleyanum var. circinatu. Compounds 2-3, 6-7, 9, and 12-16 are isolated from Aconitum hemsleyanum var. circinatum for the first time.