Construction of ginkgo flavonoids drug release system / 中草药

ABSTRACT

Objective: To construct ginkgo flavonoids drug release system based on bioavailability of ginkgo flavonoids and its clinical drug delivery behavior. Methods: Suitable oil phase, surfactant and cosurfactant were selected according to the solubility; Suitable Km value (ratio of surfactant to cosurfactant) based on the pseudo-ternary phase diagram was selected by water titration; Further prescription studies were performed at the selected Km value; The microemulsion dose was determined by HPLC; The self-microemulsion was made according to the prescription, and then the appropriate materials were added to make pellets; The preparation of pellets was evaluated. Results: Isopropyl myristate (IPM), Tween 80 and anhydrous ethanol were selected as oil phase, surfactant and cosurfactant; The Km value was 31; The ratio of total quality of Tween 80 and absolute ethanol to IPM was 91; The size of particle was less than 30 nm; Drug loading was 13.32 mg/mL. Conclusion: The pellets are stable using microemulsion as the former preparation, which improve the bioavailability of flavonoids.