Lignans and triterpenoids from roots of Kadsura longipedunculata / 中草药

ABSTRACT

Objective: To study the chemical constituents from the roots of Kadsura longipedunculata. Methods: The constituents were isolated and purified by various chromatographic methods, and the structures were identified on the basis of spectroscopic analysis. Results: Fifteen compounds including 10 lignans and five triterpenoids were isolated from the roots of K. longipedunculata and the structures were identified as (2S,3S)-4,4-bis (3,4-dimethoxyphenyl)-2,3-dimethyl-1-butanol (1), (2S,3S)-4,4-bis (4-hydroxy-3- methoxyphenyl)-2,3-dimethyl-1-butanol (2), kadangustin K (3), benzoyloxokadsuranol (4), propoxyloxokadsuranol (5), kadsutherin C (6), heteroclitin E (7), schiarisanrin C (8), heteroclitin J (9), kadsuphilin J (10), propindilactone J (11), kadcoccilactone C (12), kadsuphilactone B (13), wuweizidilactone D (14), and wuweizidilactone H (15). Conclusion: All compounds are isolated from K. longipedunculata for the first time, and compounds 1, 2, 11, and 14 are isolated from the genus Kadsura Kaempf. ex Juss. for the first time, compounds 1 and 2 are new natural products.