Chemical constituents of Adenosma glutinosum / 中草药

ABSTRACT

Objective: To study the chemical constituents of whole plant of Adenosma glutinosum. Methods: The constituents were isolated by repeated chromatography with silica gel, Sephadex LH-20, ODS, and semi-preparing liquded chromatography. The structures were elucidated by spectroscopic anaylsis. Results: Eleven compounds were isolated from the 95% ethanol extract of A. glutinosum. Their chemical structures were identified as betulinic acid (1), betulin (2), 3β-hydroxy-urs-11-en-13β, 28-olide (3), ursolic acid (4), p-hydroxybenzoic acid (5), trans-p-hydroxycinnamic acid (6), p-hydroxybenzaldehyde (7), fumaric acid (8), muconic acid (9), 5,6-dihydroxy-7,8,4'-trimethoxy-flavone (10), and 7-hydroxy-piperitone (11). Conclusion: All compounds are isolated from this plant for the first time.