Potential mechanism of Ginkgo Folium extract used in treatment of gout based on network pharmacology / 中草药

ABSTRACT

Objective: To screen the active compounds of Ginkgo Folium extrat (GFE) used in the treatment of gout to build network of compounds-target-pathway, and to elaborate the potential mechanism of GFE in the treatment of gout. Methods: The G. biloba compound-target interaction model was established by random forest algorithm, which was then applied to predict the potential targets interacted with compounds of G. biloba. The complicated compound-target-disease network of G. biloba was then constructed and analyzed. Results: Among the 158 compounds found in G. biloba, with (drug-likeness) DL ≥ 0.18 and (oral bioavailability) OB ≥ 30 as a filter condition, 39 active compounds were screened, including 11 flavonoids and 11 terpenes. There are 24 active compounds in G. biloba, which correspond to the 49 pathogenic genegenes of gout and reveal the molecular mechanism of G. biloba in the active ingredient and related targets. Conclusion: Active compounds in G. biloba may cure gout through the following three ways First, to minimize the production of uric acid; Secondly, to increase the excretion of uric acid; Thirdly, to inhibit disorders induced by NALP3 inflammation.