A new tricyclic alkaloid from twigs of Cassia fistula and its cytotoxicity / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 1650-1652, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-853509
ABSTRACT
Objective:
To study the chemical constituents in the twigs of Cassia fistula.Methods:
The chemical constituents in the twigs of C. fistula were isolated by silica gel, Sephadex LH-20 column chromatography, and RP-HPLC methods. And their structures were elucidated by using various spectroscopic techniques, including extensive 1D and 2D NMR techniques.Results:
A new tricyclic alkaloid, named as cassiarin L (1) was isolated from 95% ethanol extract of the twigs of C. fistula.Conclusion:
Compound 1 is a new compound and it displays obvious cytotoxicity against NB4, SH-SY5Y, PC3, A549, and MCF7 cells with IC50 values of 1.8, 2.6, 3.5, 4.2, and 2.3 μmol/L, respectively.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Traditional and Herbal Drugs
Ano de publicação:
2016
Tipo de documento:
Artigo
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