Improvement of extraction and concentration on quality consistency of Qiongyu Paste / 中草药

ABSTRACT

Objective: To explore the influence of extraction and concentration with long duration on the quality consistency of Qiongyu Paste (QYP), and to analyse the degradation and transformation mechanisms of each component involved in the quality change of QYP. Methods: QYP was a paste formula derived from Rehmanniae Radix, Poria, and Ginseng Radix et Rhizoma in a weight ratio of 7∶2∶1, the contents of 10 major bioactive components [5-hydroxymethyl furfural (5-HMF), catalpol, melittoside, acetoside, ginsenoside Re, ginsenoside Rb1, ginsenoside 20(S)-Rg3, ginsenoside Rg1, ginsenoside Ro, and pachymic acid] were simultaneously determined by the previously established HPLC-MS method. The standard deviation (SD) accumulation values of the contents of 10 bioactive components in repeatedly prepared samples in different durations were compared. Results: Total contents of the 10 components and relative contents of some individual components in QYP changed significantly with different extraction and concentration duration. At the same time, the SD values of the contents of bioactive components in repeatedly prepared samples decreased with extending the extraction and concentration duration. Conclusion: Extraction and concentration could improve the quality consistency of QYP.