Study on forming technique of maxing antitussive and antiasthmatic grannule / 中草药

ABSTRACT

Objective: To optimize the processing conditions of Maxing Antitussive and Antiasthmatic Grannule (MAAG). Methods: The influence of different excipients including lactose, soluble amylum, and dextrine, and usage amount of soluble amylum to hygroscopicity of powdered extract was investigated; Processing conditions were optimized by orthogonal test, flowability, and hygroscopicity were investigated. Taking forming rate, solubility, and absorption rate as indexes, the materials added prescription varieties, ratio, and optimum molding process were screened. Results: The particles sugar plus dextrin as excipients were superior to dextrin or sugar or soluble starch as excipient particles; The optimized conditions were obtained with main drug-accessories (12), accessories for the dextrin-powdered sugar (11), with 80% ethanol as wetting agent which accounted for 14% of the main drug. Conclusion: The selected accessories in MAAG is reasonable and forming process is feasible. This research provides the basis for the establishment of forming technique and control of production environment of MAAG.