Research progress on chemical constituents and pharmacological effects of alkaloids from plants of Lycoris Herb / 中草药

ABSTRACT

Recently, studies on Lycoris Herb. type alkaloids received the attention of scholars home and abroad. Lycoris Herb. type alkaloids can be devided into seven types according to their molecular structure, including lycorine type, crinine type, galanthamine type, tazettine type, narciclasine type, lycorenine type, homolycorine type, and montanine type. Researches have shown that Lycoris Herb. type alkaloids possess multiple phamocology activities, such as strong antitumor activity on human breast cancer cell (MCF-7), human leukemia cell (HL-60); and strong inhibitory effect of flu virus, measles virus, polio virus, and SARS virus; Lycorine type and crinine type alkaloids have antimalaria effect; Besides, lycorine type has strong anti-acetylcholinesterase effect. In a word, lycorine type and lycoris type alkaloids carry multiple pharmacological effect and belong to promising substances.