Effect of Aconiti Lateralis Radix Preparata on hemodynamics of rats with acute heart failure and its mechanism / 中草药

ABSTRACT

Objective: To observe the effects of Aconiti Lateralis and Radix Preparata (ALRP) on hemodynamic indexes of rats with acute heart failure (AHF) and to study its possible mechanism of α and β adrenergic receptor-related action. Methods: The AHF model in Wistar rats was induced by injecting large doses of pentobarbital. Rats were received high and low doses of ALRP as well as α and β adrenergic receptor blockers to observe the effect on hemodynamics (LVSP, HR, and ±dp/dtmax) in rats. Results: ALRP could significantly increase blood pressure, heart rate, and myocardial contractility compared with the control group (P < 0.05, 0.01), and it also exhibited a certain degree of volume-efficiency and time-effect relationship. The pressor effect of ALRP could be significantly reduced by α and β adrenergic receptor blockers. Moreover the increasing heart rate effect of ALRP could be significantly reduced by β adrenergic receptor blocker (P < 0.05, 0.01). Conclusion: ALRP can significantly enhance the cardiac function in rats with AHF and the possible mechanism of this effect is associated with α and β adrenergic receptors.