A new anthraquinone from twigs of Cassia siamea / 中草药

ABSTRACT

Objective: To study the chemical constituents in the twigs of Cassia siamea. Methods: The chemical constituents in the twigs of C. siamea were isolated by silica gel, MCI-gel resin, Sephadex LH-20 column chromatographies and RP-HPLC methods. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Results: A new anthraquinone, named as cassanthraquinone A (1) was isolated from 95% ethanol extract of the twigs of C. siamea. Conclusion: Compound 1 is a new compound and it displays the cytotoxicity against NB4, SH-SY5Y, PC3, A549, and MCF7 cells with IC50 values of 6.2, 7.8, 3.5, 8.6, and 5.4 μmol/mL, respectively.