Preparation of hyperoside solid nanocrystal and evaluation of its in vitro release / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 1759-1763, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-854125
ABSTRACT
Objective:
To prepare the hyperoside solid nanocrystal (Hyp-SN) and to determine the in vitro release.Methods:
The high pressure homogenization technology was applied to preparing Hyp nanosuspension, and then Hyp-NS was solidificated into Hyp-SN by freeze-drying. The fomulation and process of Hyp-SN were optimized by the single factor experiment. Dried powders were prepared under the optimal condition and characterized for crystallinity and particle size. In vitro dissolution of Hyp-SN was also determined.Results:
The particle size of Hyp-SN protected by tert-butyl alcohol was (405.2 ± 14.6) nm, as well as the polydispersity index (PI) was 0.25 ± 0.08. The results of SEM showed that Hyp-SN powder was irregular rod and XRD showed Hyp was crystalline in both coarse powder and nanosuspensions. In the in vitro dissolution test, Hyp-SN showed an increased dissolution markedly.Conclusion:
The method employed to prepare the Hyp-SN is simple and feasible. Hyp-SN could significantly improve the dissolution of Hyp. It has a broad application prospects.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Traditional and Herbal Drugs
Ano de publicação:
2015
Tipo de documento:
Artigo
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