Advances in studies on HIV-1 multi-target drugs from natural products / 中草药

ABSTRACT

During the curing of complex disease, prospective therapeutic effect has been more and more difficult to achieve by using single-target inhibitors. Along with the development of systems biology and network pharmacology, the nosogenesis and the pathological process have been studied in depth, and people find that multi-target inhibitors can overcome many defects by using single-target inhibitors. Multi-target inhibitors include multicomponent and single component, but single component takes more advantages. The treatment of AIDS is a world problem, single-target inhibitors and multicomponent multi-target inhibitors (i.e. HAART) are used; However, viral height variability and severe drug resistance restrict the wide application of the two therapeutics. Therefore, the single component multi-target inhibitors with low toxicity and highperformance have been the most important choice to treat AIDS caused by HIV-1. The single component multi-target HIV-1 inhibitors mostly come from rational drug design and screening. Some HIV-1 inhibitors have been discovered from the natural products which have extensive sources and wide variety of kinds. That is an important way to develop lead compounds of HIV-1 inhibitors. This paper summarizes the advances in studies on HIV-1 multi-target drugs from natural products.