Optimization of preparation technology of colon-specific chitosan microspheres of rhubarb total anthraquinones / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 38-42, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-854153
ABSTRACT
Objective:
To optimize the preparation technology of colon-specific chitosan microspheres of rhubarb total anthraquinones (RTA-CMS).Methods:
With chitosan as material, RTA was made into microspheres. According to the entrapment efficiency (EE) and particle diameter, the best preparation technology was selected using orthogonal design. The enteric material Eudragit S100 was used to coat the CMS.Results:
The best preparation technology was as follows The concentration of chitosan was 2.5%; The mass ratio of RTA and chitosan was 14; The ratio of paraffin and dichloromethane was 11; The amount of span-80 was 2%. The EE of CMS was 64.5%. The particle diameter of the CMS was (248.8 ± 54.2) μm, and the mean diameter was (269.3 ± 172.7) μm after coating.Conclusion:
RTA-CMS prepared with the best preparation technology has a high EE. And the microspheres form is good. The technology could be used to prepare colon-specific RTA-CMS.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Traditional and Herbal Drugs
Ano de publicação:
2015
Tipo de documento:
Artigo
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