Pharmacodynamics study on in vivo anti-oxidant action of Buyang Huanwu Decoction in mice / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 96-100, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-854163
ABSTRACT
Objective:
To study the in vivo pharmacodynamics characteristics of Buyang Huanwu Decoction (BHD) in mice, and to provide reference for rational clinical drug use.Methods:
The level of MDA and activity of SOD in liver tissue of mice were determined after ig treatment with BHD or its drug-containing serum. Further more, the time-effect and dose-effect relationship of BHD on MDA level and SOD activity were carried out. The parameters of pharmacodynamics were estimated based on the time-effect and dose-effect curves.Results:
Compared with control group, both BHD and its drug-containing serum could reduce MDAlevel, while raise SOD activity in the liver of mice (P < 0.05). Time-effect curves both present multi-peak but most pharmacodynamics parameters showed significant differences (P < 0.05), except tp and t1/2(Ka).Conclusion:
BHD has obvious antioxidant effect and pharmacodynamics characteristics can be described as one-compartment model.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Chinese Traditional and Herbal Drugs
Ano de publicação:
2015
Tipo de documento:
Artigo
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