Pharmacodynamics study on in vivo anti-oxidant action of Buyang Huanwu Decoction in mice / 中草药
Chinese Traditional and Herbal Drugs
; (24): 96-100, 2015.
Article
em Zh
| WPRIM
| ID: wpr-854163
Biblioteca responsável:
WPRO
ABSTRACT
Objective: To study the in vivo pharmacodynamics characteristics of Buyang Huanwu Decoction (BHD) in mice, and to provide reference for rational clinical drug use. Methods: The level of MDA and activity of SOD in liver tissue of mice were determined after ig treatment with BHD or its drug-containing serum. Further more, the time-effect and dose-effect relationship of BHD on MDA level and SOD activity were carried out. The parameters of pharmacodynamics were estimated based on the time-effect and dose-effect curves. Results: Compared with control group, both BHD and its drug-containing serum could reduce MDAlevel, while raise SOD activity in the liver of mice (P < 0.05). Time-effect curves both present multi-peak but most pharmacodynamics parameters showed significant differences (P < 0.05), except tp and t1/2(Ka). Conclusion: BHD has obvious antioxidant effect and pharmacodynamics characteristics can be described as one-compartment model.
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Índice:
WPRIM
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Revista:
Chinese Traditional and Herbal Drugs
Ano de publicação:
2015
Tipo de documento:
Article