Structural modification and biological evaluation of monomeric compound from Pandanus tectorius / 中草药

ABSTRACT

Objective: To modify the structure of natural monomeric compound 3-O-caffeoylquinic acid from medicinal plant Pandanus tectorius, and evaluate the anti-influenza virus activity of the derivatives. Methods: Applying 3-O-caffeoylquinic acid as material, the target compounds were prepared by three routes and evaluated for their anti-influenza virus effects by MDCK cells in vitro. Results: Thirteen caffeoylquinic acid derivatives B1-B13 were synthesized. The structures of the target compounds were identified by spectrum. Pharmacological results showed that the compounds B4, B6, and B10 had the different potencial inhibition on the replication of influenza virus in cells. Conclusion: The new compounds B2 and B4-B13 which show the potential biological activity of anti-influenza virus, have not been reported in any literatures and are worth studying further.