Advances in study on baicalein for regulation of signaling pathways in myocardial ischemia/hypoxia / 中草药

ABSTRACT

Myocardial ischemia/hypoxia often results in damaging the structure and function of heart. Baicalein, a widely distributed flavonoid, has been shown to play an important role in the cardioprotection of ischemia/hypoxia in recent years. The cardioprotection of baicalein was mediated by regulating the cell signaling pathways and controlling the phosphorylation of key signaling molecules. These signaling pathways involved in phosphatidylinositol-3-kinase-serine/threonine kinase (PI3K/Akt), mitogen-activated protein kinase (MAPKs), and nuclear factor-κB (NF-κB), and their down signaling proteins HMGB1, MMP-2/-9, and eNOS, and apoptosis proteins as well. The interaction mechanism of baicalein on signaling pathway in myocardial ischemia/hypoxia has been reviewed.