Advances in studies on Chinese materia medica for treatment of ulcerative colitis based on NF-κB signal pathway / 中草药

ABSTRACT

Ulcerative colitis (UC) is a chronic and relapsing condition of the intestinal inflammation of unknown etiology and remains one of the most intractable gastrointestinal diseases, impairing quality of life and carrying a high risk of colorectal cancer in patients with UC. Currently, aminosalicylic acid, steroid hormone, and immunosuppressor are the main drugs for treating UC. However, all of them can not cure UC once and for all. In recent years, many scholars attempted to find new drugs in the extracts and active compounds from herbs for the prevention and treatment of UC. The paper summarized the status of nuclear factor kappa B (NF-κB) signal pathway of UC, and those anti-inflammation Chinese materia medica regarded proteins and enzymes of NF-κB pathway as targets.