Chemical constituents from stems of Syzygium jambos var. jambos and their in vitro cytotoxicity / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 1993-1997, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-854451
ABSTRACT
Objective:
To study the chemical constituents from the stems of Syzygium jambos var. jambos.Methods:
The phyotchemicals were isolated by using various chromatographic techniques such as silica gel, Sephadex LH-20, alumina column chromatography, and preparative HPLC process. The structures were elucidated on the basis of spectral data analysis. Their cytotoxicity against human liver cancer cells Huh-7 was conducted using MTT assay.Results:
Twelve compounds were isolated from the EtOAc and MeOH extracts in the stems of S. jambos and identified as alphitolic acid (1), urolithin A (2), dibutyl phthalate (3), betulinic acid (4), ursolic acid (5), 1-(4-methoxyphenyl)-1, 2-propanediol (6), 2, 6-dimethoxy-1, 4-benzoquinone (7), diisobutyl phthalate (8), β-sitosterol (9), 3-acetyl-ursolic acid (10), asiatic acid (11), and arjunolic acid (12), respectively. All tested compounds 1, 7, 10, and 11 + 12 mixture did not show the cytotoxic activities towards human tumor cells Huh-7 in the test range up to 50 μmol/L.Conclusion:
Except compound 4, the other 11 compounds are obtained from this plant for the first time. All tested compounds exhibit no significant cytotoxic activity against Huh-7 cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Traditional and Herbal Drugs
Ano de publicação:
2014
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS