Paparation of solid dispersion of Kyllinga brevifolia total flavonols and its properties / 中草药

ABSTRACT

Objective: To prepare the solid dispersion of Kyllinga brevifolia total flavonols (KBTF) for improving the dissolution rate of KBTF. Methods: The solid dispersion was prepared by the melted and dissolved method with the carriers of PVP K30, PEG 6000, PEG 4000, and Poloxamer 188 and the in vitro dissolution of KBTF solid dispersions was performed. The structure of the solid dispersion was characterized by SEM and IR. Results: The solid dispersion prepared with PVPK30 as carrier is better to improve the dissolution than those with other carriers, and drug-carrier (12) is the best. The results of SEM and IR showed that KBTF in solid dispersion took amorphous form. Conclusion: The solid dispersion technology can significantly increase the dissolution of KBTF in vitro.