Analysis on in vivo metabolites of α-hederin in rats by UPLC-MS/MS / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 1883-1888, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-854488
ABSTRACT
Objective:
To investigate the metabolites of α-hederin in feces of rats after ig administration.Methods:
An UPLC-Q/Trap-MS method was used for the identification of metabolites of α-hederin in feces of rats after ig administration of α-hederin (150 mg/kg).Results:
Seven metabolites were detected in rat feces, including demethylation of α-hederin (M1), 3-O-α-L-arabinopyranoside hederagenin (M2), hederagenin (M3), glucuronideconjugate of α-hederin (M4), and double bond bonus of α-hederin (M5, M6-1, and M6-2).Conclusion:
α-Hederin experiences a variety of metabolic reactions in rat gastrointestinal tract, mainly including deglycosylation, glucuronidation, demethylation, etc.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Traditional and Herbal Drugs
Ano de publicação:
2014
Tipo de documento:
Artigo
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