Anti-gout effect of Poecilobdella manillensis / 中草药

ABSTRACT

Objective: To observe the therapeutic effects on gout and the acute toxicity of Poecilobdella manillensis. Methods: The anti-gout effects of P. manillensis were studied by observing its effects on the hyperuricacidemia model and the level of blood uric acid. And we observed the effect of P. manillensis on gouty inflammation via injection of MSU to the foot of rats. The analgesic effect and toxicity of P. manillensis will be reported in this work too. Results: Comparing with the model group, P. manillensis could significantly reduce the level of the blood uric acid in the hyperuricemic and normal mice at 3.00 and 1.50 g/kg doses (P < 0.01), and acute gouty arthritis at 0.75 g/kg dose (P < 0.05, 0.01). It reduced the number of writhing in mice at 3.00 and 0.75 g/kg doses (P < 0.05, 0.01). Obvious toxic reaction was not observed and the maximum tolerant dose was 23.09 g/kg for mice in acute toxicity experiment. Conclusion: P. manillensis is proved to have the therapeutic effect on gout. Further research and development will be continued.