Correlation research between in vivo tissue distribution in rats and channel tropism of active constituents in dried ginger / 中草药

ABSTRACT

Objective: To observe the in vivo tissue distribution of 6-gingerols, 6-shogaol, and 8-gingerols from dried ginger (the rhizome of Zingiber officinale) in rats and to discuss the channel tropism of them. Methods: The method of "symptoms-efficacy-pharmacokinetics" was used and the ginger solution was ig given to the rats which were deficiency-cold in spleen and stomach; Then the blood, heart, liver, spleen, lung, kidney, brain, stomach, large intestine, and small intestine were immediately taken out after the rats were ig given the medince in 10, 20, 40, 60, 80, 120, and 360 min, respectively; Finally, HPLC was used to detect the concentration of 6-gingerols, 6-shogaol, and 8-gingerols from dried ginger in different tissues of rats in each group of deficiency-cold in spleen and stomach and normal by calculating the pharmacokinetic parameters. Results: We found that in the group of deficiency-cold in spleen and stomach, the concentration of the three active components was the highest in stomach, small intestine, liver, and lung, and in the group of normal, the three components were mostly distributed in the stomach, kidney, small intestine, large intestine, and lung. What's more, in the digestive organs, such as stomach and small intestine, the concentration was obviously higher in the group of deficiency-cold in spleen and stomach than that in the group of normal. Conclusion: The main ingredients of dried ginger mostly distribute in spleen, stomach, lung, and liver. This view conform to the traditional channel trpism of dried ginger in traditional Chinese medicine theory.