Chemical constituents of Ainsliaea latifolia / 中草药

ABSTRACT

Objective: To isolate and identify the chemical constituents of Ainsliaea latifolia. Methods: Compounds were isolated by various kinds of column chromatographies on silica gel, Sephadex LH-20, MPLC, and HPLC, and their structures were elucidated by the physicochemical properties and spectral analyses. Results: Thirteen chemical constituents were obtained and identified as friedelin (1), taraxeryl acetate (2), 3β-hydroxy-11α, 12α-epoxy-friedoolean-14-ene (3), careborin (4), cis-careborin (5), 3α-E-feruloyltaraxerol (6), 3α-Z-feruloyltaraxerol (7), 3-oxo-11α-methoxyolean-12-ene (8), diaspanolide A (9), diaspanolide B (10), ainsliaolide A (11), stigmasterol (12), and β-sitosterol (13). Conclusion: Among the isolated 13 compounds, there are 8 triterpenoids (1-8), 3 sesquiterpenoids (9-11), and 2 steroidals (12-13). All the compounds are isolated from A. latifolia for the first time.