Chemical constituents in endophytic fungus Verticillium sp. KY-18 isolated from Dendrobium officinale / 中草药

ABSTRACT

Objective: To study the chemical constituents in the endophytic fungus Verticillium sp. KY-18, isolated from Dendrobium candidum. Methods: The compounds were isolated and purified by means of chromatographic techniques and their structures were identified on the basis of spectral features. Results: Thirteen known compounds belong to oxygen heterocyclic compounds, named 2, 6-dihydroxy-2-methyl-7-(prop-1E-enyl)-1-benzofuran-3 (2H)-one (1), nigrosporapyrone D (2), oosponol (3), 2-methyl-4-pyrone (4), 5-(1E-butenyl)-6-methylpyran-2-one (5), penicisochroman D (6), verrucosapyrone B (7), (1S, 3S)-1, 8-dimethoxy-3, 5- dimethyl-6-hydroxyisochroman (8), phomopsinone A (9), pseudohalonectrin A (10), dictafolin-A (11), 2, 3-dihydro-5, 7-dihydroxy-2, 6, 8-trimethyl-4H-1-benzopyran-4-one (12), and 2-pyrone-4, 6-dicarboxylic acid (13). Conclusion: Compounds 2-10 are first isolated from the plants of Verticillium genus, and compounds 11-13 are first obtained from fungi.