Meta-analysis on Wenxin Granules in treatment of arrhythmia / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 2277-2282, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-854943
ABSTRACT
To evaluate the efficacy and safety of Wenxin Granules (WG) in the treatment of arrhythmia using Meta-analysis. Cochrane library, PubMed database, Medline (Ovid) and MEDLINE In-Process & Other database, Embase (Ovid) Database, CNKI Database, VIP Database, and Wanfang Database were searched until June, 2013. The data of randomized controlled trials (RCT) of WG were chosen and extracted by two reviewers independently according to inclusion and exclusion criteria, and cross-checked and assessed in the quality and methodology. Meta analysis on all the data arecarriee out by using RevMan 5.0 software. There are totally 25 trials and 2 947 patients included. In the aspect of the effect of anti-arrhythmia WG is better than Propafenone (OR=2.07; 95% CI 1.52-2.83; P<0.00001), Metoprolol (OR=3.68; 95% CI 2.11-6.41; P<0.00001), Mexiletine hydrochloride (OR=3.16; 95% CI 1.75-5.72; P<0.0001), but is not significantly different with Amiodarone (OR=1.29, 95% CI 0.90-1.85; P=0.16); In the improvement of ECG WG is better than Propafenone (OR=2.39; 95% CI 1.72-3.34; P<0.00001), but is not significantly different with Metoprolol (OR=1.80; 95% CI 0.69-4.67; P=0.23); In the aspect of safety the rate of gastric adverse reactions caused by WG is lower than that caused by Amiodarone (OR=0.54; 95% CI 0.29-0.98; P=0.04); The rate of arrhythmia adverse reaction caused by WG is lower than that caused by amiodarone (OR=0.05; 95% CI 0.02-0.16; P<0.00001). Conclusion:
WG is effective and safe for arrhythmia, but more clinical study should be done to confirm the effective and safety.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Ensaio Clínico Controlado
/
Revisões Sistemáticas Avaliadas
Idioma:
Chinês
Revista:
Chinese Traditional and Herbal Drugs
Ano de publicação:
2014
Tipo de documento:
Artigo
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