Influence of prenylation at C-8 of ring A of flavonoid on bioactivity of parent compound / 中草药

ABSTRACT

The flavonoids with the prenylation on site 8 are a unique class of natural flavonoids. The existence of prenyl-moiety could dramatically increase the lipophilicity and the relevant bioactivities of flavonoids. This review discussed the influences of the prenylation at C-8 of ring A in flavonoids on the activities of antioxidant, anti-bone resorption, antimicrobial activity, anti-tumor activity, and tyrosinase inhibition of the backbone flavonoids.