Chemical constituents from roots of Ficus auriculata / 中草药

ABSTRACT

Objective: To study the chemical constituents from the roots of Ficus auriculata. Methods: The chemical constituents were isolated and purified by various chromatographic methods, including silica gel, ODS, Sephadex LH-20 columns, and recrystallization. Structures of the isolated compounds were elucidated based on NMR and ESI-MS data, as well as physicochemical properties. Results: Thirteen compounds were obtained in the EtOAc fraction of ethanol extract from the roots of F. auriculata and identified as β-sitosterol (1), α-amyrin (2), 6β-hydroxystigmast-4-en-3one (3), stigmasta-3, 6-dione (4), (22E, 24S)-24-methyl-5α- choleata-7, 22-diene-3β, 5, 6β-triol (5), 3-(1-hydroxyethyl)-7-hydroxy-1-isobenzofuranone (6), (R)-(+)-de-O-methyllasiodiplodin (7), decursinol (8), (-)-3, 5-dimethyl-8-methoxy-3, 4-dihydroisocoumarin (9), (R)-(-)-mellein methyl ether (10), 5-formyl-8-hydroxy-3, 4-dihydroisocoumarin (11), (R)-(-)-5-methoxycarbonyl mellein (12), and β-daucosterol (13). Conclusion: All the compounds except compound 1 are firstly isolated from F. auriculata, and compounds 4-12 are found in the plants of Ficus Linn. for the first time.