Optimization of one-step pelletization technology of Tianshu Capsule by Minitab / 中草药

ABSTRACT

Objective: To optimize the one-step pelletization technology of Tianshu Capsule by Minitab software. Methods: Using the qualified rates of particles as the evaluation indexes, three significant impact factors (fluid extract-dextrin ratio, infusion frequency, and atomization pressure) of one-step pelletization technology were selected and the levels of non-significant factors were identified by the Plackett-Burman experimental design. According to single factor experiments, choosing the qualified rates of particles, moisture, and angle of repose as the evaluation indexes, three levels of the three factors were selected by Box-Behnken of central composite design to establish the multiple linear regression and binomial fitting, and the experimental data were optimized by the response optimizer. Results: The best conditions were as follows fluid extract-dextrin of 1.571 put in fluid-bed and heated by fan; the temperature of the bottom material in the fluidized state was increased to 50°C, fluid extract of 2% HPMC was sprayed with frequency of 32 Hz, the frequency of fan was 30 Hz, inlet air temperature was 60°C, atomization pressure was 0.21 MPa, and feed temperature was 50°C. Conclusion: Under the Minitab optimized scheme, the average experimental results are similar to the predicted values, and Minitab software could be used in the optimization of one-step pelletization for Chinese materia medica.