Hygroscopicity of Liuwei Dihuang powder and its correlation of physical properties / 中草药

ABSTRACT

Objective: To investigate the hygroscopic properties of Liuwei Dihuang extract, and the correlation between the tensile strength and physical properties such as moisture content, angle of repose, critical relative humidity (CRH), and Karnofsky index. Methods: Liuwei Dihuang extract was used as a model, added with various excipients in different ways, and their hygroscopic properties were examined. Using the method of multiple linear regression analysis, the correlation between tensile strength and the physical properties of Liuwei Dihuang raw materials was studied. Results: The hygroscopicity of Liuwei Dihuang extract with various excipients was improved, negatively correlated with angle repose, compression index, bulk density, and moisture acceleration, and positively correlated with water solubility, water content, CRH, equilibrium moisture content, and initial velocity of hygroscopicity. Conclusion: The physical properties of Liuwei Dihuang powder affects the tensile strength of its tablets formed directly.