Preparation of self-assembled beads drug delivery system of tripterine based on cyclodextrin and oil as well as its in vitro evaluation / 中草药

ABSTRACT

Objective: To prepare the self-assembled beads drug delivery system of triptrine based on cyclodextrin and oil, and to carry out its in vitro evaluation. Methods: The beads were prepared by a continuously shaking starting from a mixture of cyclodextrin aqueous solution and oil. The bead diameter and drug distribution were investigated by microscopic observations, and drug disperse state was observed by differential scanning calorimetry (DSC). The drug-loading and entrapment efficiency of tripterine in beads were investigated by HPLC. The in vitro dissolution of tripterine in beads was also determined. Results: The diameter was in the range of (1.49 ± 0.20) mm. The drug-loading and encapsulation efficiency of the prepared beads were (87.21 ± 0.58) μg/g and (80.14 ± 1.24)%, respectively. DSC suggested that tripterine existed as amorphous form in beads. Confocal microcopy showed that the hydrophobic drug was localized inside the beads. The maximum cumulative release amount of tripterine in simulated intestinal fluid was more than 80% at 6 h. Conclusion: The formulation and preparation process are practical and simple, and these beads have great potentialities for carrying hydrophobic drug.