Effects of Inonotus obliquus fungal substance on type 2 diabetic rats induced by Streptozotocin / 中草药

ABSTRACT

Objective: To compare the effects of fungal substance and sclerotium in Inonotus obliquus on the expeimental rats with type 2 diabetes mellitus induced by Streptozotocin (STZ). Methods: The type 2 diabetic rat model was established by ip injection of STZ (35 mg/kg) on SD rats after the rats were fed with high sugar and high fat for 6 weeks. Then, the rats were divided into model, fungal substance (I. obliquus fungal substance 1 g/kg), sclerotium (I. obliquus sclerotium 1 g/kg), and positive control (metformin hydrochloride 0.2 g/kg) groups. After 10 weeks of administration, the body weight, fasting blood glucose (FBG), insulin (INS), glycated metabolism (HbAlc), free fatty acid (FFA), cholesterin (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-Px), and other blood biochemical indexes were measured, and the oral glucose tolerance test (OGTT) was carried out. Results: After 10 weeks of administration, compared with the model group, the body weight and the SOD and GSH-Px levels of diabetic rats were significantly increased in fungal substance and sclerotium groups (P < 0.05), and the blood glucose and FBG, FFA, TC, TG, and MDA levels in the serum of diabetic rats were significantly decreased (P < 0.05). The effects between fungal substance and sclerotium groups were statistically nonsignificant on the above indexes. Conclusion: The fungal substance of I. obliquus could relieve the symptom, lower the blood glucose, regulate the blood lipid, and improve the oxidative stress of experimental rats with type 2 diabetes mellitus, and the effects are similar with sclerotium group of wild I. obliquus.