Sustained-release solid dispersion of tripterin carried by colloidal silia dioxide / 中草药

ABSTRACT

Objective: To prepare the sustained-release solid dispersion of tripterin (SRSDT) with the intention of improving drug dissolution, meanwhile, the drug release was slowed down so as to make the toxicity diminished. Methods: SRSDT was prepared by the solvent method with colloidal silica dioxide (CSD) as carrier. The physical characteristics and in vitro release rate were further evaluated. Results: The ideal SRSDT was prepared by mixing tripterin and colloidal silica dioxide with the weight ratio of 112; The release rate of drug could keep moderate and controllable. In vitro cumulative release of SRSDT was up to more than 90% after 8 h. The results of differential scanning calorimetry, scanning electron microscopy, and X-ray powder diffraction could prove that the tripterin existed as amorphous form in the carrier. Conclusion: The SRSDT carried by CSD could control the release rate of drug and keep moderate and controllable, and the preparation process is simple, which has potential applications.