Impurity removal technology of Qihong Maitong Injection mixing liquid / 中草药
Chinese Traditional and Herbal Drugs
; (24): 696-700, 2013.
Article
em Zh
| WPRIM
| ID: wpr-855447
Biblioteca responsável:
WPRO
ABSTRACT
Objective: To optimize the impurity removal technology before ultrafiltration, taking Qihong Maitong Injection (QMI) as the research object. Methods: The removal of impurities and related substances by the combined process of refrigeration, centrifugation, and activated carbon adsorption was investigated. Taking the contents of total saponins of astragalus, astragaloside, and hydroxy safflower yellow pigment A, solids reduction efficiency, protein concentration, and related substances inspection as the evaluation indexes, the feasibility of the impurity removal method was definited and the process parameters were optimized. Results: The optimized process parameters were as follows: refrigerated for 24 h, centrifugated for 15 min, at 5 000 r/min, activated carbon dosage of 0.3%, temperature 40 °C, adsorption time 30 min, and the original solution pH value. Conclusion: The impurity removal effect of refrigeration, centrifugation, and activated carbon adsorption is significant, which could effectively remove the resin, protein, and other impurities.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Traditional and Herbal Drugs
Ano de publicação:
2013
Tipo de documento:
Article