Chemical constituents of antineoplastic actinomycete strain (N2010-37) of bottom mud in mangrove (I) / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 2173-2176, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-855505
ABSTRACT
Objective:
To study the chemical constituents in the cultured filaments of an antitumor actinomycete strain (N2010-37).Methods:
Compounds were isolated and purified by chromatographic techniques and recrystallization, and the structures were identified by spectral methods together with physicochemical analysis. The antitumor effects of these compounds were tested in vitro by MTT method.Results:
Three compounds were identified including two anthrones and one novel macrolide. They were (3S, 4R, 7R, 8R, 9S)-3, 8-dihydroxy-4, 7,9-trimethyl-2,6-cyclononanediiolacetone (1), 2-hydroxy-1-methoxy-3- methylanthraquinone (2), and 1, 6, 8-thihydroxy-3-methylanthraquinone (3).Conclusion:
Compound 1 is a new compound, and compounds 1 and 3 show the favorable cytotoxic activity against human chronic granulocytic leukemia cell line K562 strain by MTT method in vitro.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Traditional and Herbal Drugs
Ano de publicação:
2011
Tipo de documento:
Artigo
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