Optimization of solid lipid nanoparticles of silymarin by using Box-Behnken experimental design / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 2221-2225, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-855511
ABSTRACT
Objective:
To optimize the formulation parameters of solid lipid nanoparticles (SLN) of Silymarin by Box-Behnken experimental design.Methods:
A three-factor and three-level Box-Behnken experimental design was employed using emulsion evaporation-low temperature solidification technique to prepare SLN with Silymarin as model drug. Response surface methodology was used to investigate the factors affecting entrapment efficiency (EE), drug loading (DL), and particle size. Binomial mathematical model-optimized formulation was established with EE, DL, and particle size as response values.Results:
The optimal formulation was as follows the amount of glycerol monostearate was 5.05%, the concentration of Poloxamer 188 was 7.25%, and the amount of drug was 15%.Conclusion:
The Box-Behnken experimental design could be used to optimize the SLN of silymarin.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Chinese Traditional and Herbal Drugs
Ano de publicação:
2011
Tipo de documento:
Artigo
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