Influence of superfine grinding on physicochemical properties of Drynariae Rhizoma / 中草药

ABSTRACT

Objective: Comparing the powder characteristics and dissolution rate between common powder and micropowder of Drynariae Rhizoma to provide experimental evidence for the micropowder application and the control of paticle size. Methods: Particle size and distribution, hygroscopicity, and powder morphology of the powder characteristics and dissolution behavior were used to evaluate the impact of particle size on powder characteristics and dissolution of Drynariae Rhizoma powders. Results: There were significant differences between common powder and micropowder in powder characteristics and dissolution rate. In addition to the micropowder III, the dissolution rates and the concentrations of naringin in micropowders were higher than those in the common powder of Drynariae Rhizoma. Conclusion: An appropriate degree of micronization is helpful for the dissolution of the active components in Drynariae Rhizoma and the application of micronization technology to Drynariae Rhizoma is feasible. The particle diameter (D90) of the micropowders should be controlled in 61.4-23.5 μm.