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Correlation evaluation of transdermal delivery in vitro and in vivo with Zhibitong Cataplasm / 中草药
Chinese Traditional and Herbal Drugs ; (24): 484-486, 2011.
Artigo em Chinês | WPRIM | ID: wpr-855653
ABSTRACT

Objective:

To investigate the correlation of transdermal delivery in vitro and in vivo with Zhibitong Cataplasm.

Methods:

Single-chamber diffusion cell was used and sinomenine concentration was determined by HPLC in vitro. In vivo tests, W-N method was applied to calculating the cumulative absorption of concentration by plasma drug concentration in rats. And the linear regression equation was figured through the concentration of cumulative in vitro and the concentration of cumulative absorption in vivo.

Results:

The regression equation was Y=0.097 24 X+0.323 91, r=0.955 1 and there was a high correlation between in vitro transdermal delivery and in vivo percutaneous absorption.

Conclusion:

This method can be used to evaluate the correlation between in vitro and in vivo transdermal delivery.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Traditional and Herbal Drugs Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Traditional and Herbal Drugs Ano de publicação: 2011 Tipo de documento: Artigo