Function and regulation of miRNAs associated with Parkinson's disease / 中国临床药理学与治疗学

ABSTRACT

Parkinson's disease (PD) is a common neurological degenerative disease in the elderly people. The causes of PD are complicated, and its pathogenesis is still unknown. At present, it is generally believed that the occurrence of PD is related to multiple factors such as environment, genetics and age. microRNAs (miRNAs) are endogenous small non-coding RNAs that are involved in regulating about one-third of genes in the human genome at post-transcription level. A large number of studies have shown that miRNAs play important roles in PD. This review discusses recent researches on miRNAs relevant to PD, and summarizes the specific expression of miRNAs in the pathogenesis and diagnosis of PD.