Ginsenoside Rg1 in the treatment of nonalcoholic fatty liver disease / 中国临床药理学与治疗学

ABSTRACT

Nonalcoholic fatty liver (NAFLD) is a substantial pathological change of the liver caused by no excessive alcohol intake or genetic predisposition. It can further develop into non-alcoholic steatohepatitis, liver cirrhosis, hepatocellular carcinoma, liver failure. Studies have shown that non-alcoholic fatty liver is also closely related to a variety of metabolic diseases, such as type 2 diabetes mellitus(T2DM), hypertension, cardiovascular disease and so on. However, its pathogenesis is not clear, and there is a lack of drugs for clinical treatment. Ginsenoside Rg1 has a wide range of effects, such as antioxidation, anti-aging, anti-inflammatory reaction, auxiliary treatment of diabetes and so on. In this paper, the pathogenesis of NAFLD and the research progress of Rg1 in NAFLD are reviewed.