Common risk factors and its impact on the age of onset in young female patients with cerebral infarction / 中国脑血管病杂志

ABSTRACT

Objective: To investigate the common risk factors, clinical features and the impact of risk factors on the age of onset in young female patients with cerebral infarction. Methods: The clinical data of 260 young female patients with new cerebral infarction were analyzed retrospectively. The common risk factors and the impact of risk factors on the age of onset in young women with cerebral infarction were observed. Results: Circled digit oneAmong the 260 patients, 36-45 years were the majority (65.8%) and 18-25 years were the minority (11.5%). Their most common risk factors were hypertension (39. 2%), diabetes mellitus(14.6%) and hyperlipidemia (8.1%); followed by other risk factors, such as moyamoya disease (3.8%), patent foramen ovale (4.2%), hyperhomocysteinemia (3.5%), vasculitis (3.5%) and atrial fibrillation (3.5%). The incidence of hypertension increased with age (χ2 = 17. 573, P < 0.01), and patent foramen ovale decreased with age (χ2 =12.666, P<0.01). Circled digit twoThe TOAST criteria; cryptogenic type accounted for 31.2% (81/260); large-artery atherosclerotic type accounted for 26.9% (70/260); small-artery occlusion and other definitive cause types accounted for 16.5% (43/260) and 15.0% (39/260) respectively; and cardioembolic type accounted for 10.4% (27/260). Circled digit threeLogrank test analysis did not find that the age of stroke onset in patients with hypertension, diabetes, hyperlipidemia and atrial fibrillation was lower than the mean age; and the age (median age [95% CI]) of the occurrence of cerebral infarction in patients with atrial septal defect, patent foramen ovale and vasculitis were 26 (range 13-39), 29 (range 19-39), and 35 (range 33-37) years, respectively. They were lower than the average age of this group [39 years range 38-40] , all P < 0.05). Conclusion: The most common risk factors in young female patients with cerebral infarction are hypertension, diabetes, hyperlipidemia, moyamoya disease, and patent foramen ovale. Hyperhomocysteinemia and vasculitis also have a higher proportion. Among the patients with atrial septal defect, patent foramen ovale and vasculitis, the age of the occurrence of cerebral infarction is younger.