The Combined Pituitary Stimulation Test in Patients Suffered from Massive Postpartum Hemorrhage / 대한내분비학회지
Journal of Korean Society of Endocrinology
; : 39-53, 2001.
Article
em Ko
| WPRIM
| ID: wpr-85607
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: ackground: Sheehan's syndrome secondary to severe postpartum hemorrhage is one of the major causes of pituitary insufficiency in Korea. Most of these patients do not manifest symptoms or signs of gross endocrinopathies. Earlier detection of pituitary insufficiency is of clinical importance. The combined pituitary stimulation test that uses the four hypothalamic releasing hormones is a rapid, safe, and effective way to evaluate anterior pituitary function. However, the criteria for a normal response has not been established in Korea. METHODS: Combined anterior pituitary stimulation tests were performed on fourteen healthy women who had no history of endocrine disease. Combined tests of anterior pituitary reserve were done no forty-five patients who suffered from massive postpartum hemorrhage which required transfusing, along with subsequent shock or changing consciousness and in thirty-nine patients who experienced mild postpartum hemorrhage. RESULTS: 1) In the severe hemorrhage group, thirty-three of forty-five women (73.3%) showed blunted responses in more than one of the anterior pituitary hormones in the combined pituitary stimulation tests. However, in the mild hemorrhage group, only eighteen of thirty-nine women (46.2%) demonstrated blunted responses of more than one of the anterior pituitary hormones. 2) In the severe hemorrhage group, the TSH response was blunted in twenty-five patients (55.6%), prolactin in eleven patients (24.4%), ACTH in ten patients (22.2%), LH in ten patients (22.2%), GH in nine patients (20%), and FSH in five patients (11.1%). 3) The results of combined pituitary stimulation tests in the normal control group were different from the results of other studies. CONCLUSION: It is recommended that the women who experienced a severe postpartum hemorrhage should be evaluated by using the combined pituitary stimulation test. Moreover, criteria for a normal response to the combined pituitary stimulation test should be established in Korea.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Hormônios Adeno-Hipofisários
/
Prolactina
/
Choque
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Hormônios Liberadores de Hormônios Hipofisários
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Hormônio Adrenocorticotrópico
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Estado de Consciência
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Período Pós-Parto
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Doenças do Sistema Endócrino
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Hemorragia
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Hemorragia Pós-Parto
Limite:
Female
/
Humans
País/Região como assunto:
Asia
Idioma:
Ko
Revista:
Journal of Korean Society of Endocrinology
Ano de publicação:
2001
Tipo de documento:
Article