Correlation between apparent diffusion coefficient and brain metabolites in infarct area of patients with acute cerebral infarction / 中国脑血管病杂志

ABSTRACT

Objective: To investigate the changes of brain metabolites of apparent diffusion coefficient (ADC) in infarct area after acute cerebral infarction and the correlation between the ADC values and brain metabolites. Methods: Thirty-two consecutive patients with acute cerebral infarction were enrolled in the study. They were all performed head MR scan, magnetic resonance diffusion weighted imaging (DWI) , ADC map and magnetic resonance spectroscopy (MRS). The ADC values and the content of N-acetyl aspartate (NAA), choline, creatine, and lactic acid were measured in the central and peripheral area of infarction, peripheral normal brain tissue, and the contralateral mirror image area of the central area of infarction (mirror image area). The correlation analyses between ADC values and NAA, choline, creatine, and lactic acid were performed. Results: Circled digit oneCompared with the contralateral mirror image area, the ADC value decreased significantly in the central area of infarction, and the ADC value decreased mildly in the peripheral area (P < 0.01). The ADC values did not change significantly in the peripheral normal brain tissue. Circled digit twoCompared with the contralateral mirror image area, the NAA content decreased significantly and the lactic acid content increased significantly in the central area of infarction. The NAA content decreased mildly and the lactic acid content increased mildly in the peripheral area. There were no significant changes in the NAA and lactic acid in the peripheral normal brain tissue. There were no significant differences in the choline content in the peripheral area of infarction, peripheral normal area and mirror image area, but they were all higher than that in the central area of infarction, and the differences were significant (P <0.05, P < 0.01). Circled digit threeAfter acute cerebral infarction, the ADC value of brain tissue was positively correlated with the NAA content (rs = 0.196, P = 0.027), negatively correlated with the lactic acid content (rs = - 0.381 , P = 0.000), and was not correlated with the choline content (rs = 0.088, P = 0.326). Conclusion: The ADC value, NAA, choline and choline content changed in the central area of infarction and peripheral area after acute cerebral infarction. The changes of ADC values has a certain correlation with the NAA and lactic acid content.