The Effects of Moxifloxacin in Endotoxin-induced Acute Lung Injury / 대한흉부외과학회지
The Korean Journal of Thoracic and Cardiovascular Surgery
; : 1-8, 2009.
Article
em Ko
| WPRIM
| ID: wpr-85645
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: The pathophysiology of acute respiratory distress syndrome with sepsis is acute lung injury (ALI) that's' caused by endotoxin (LPS). We evaluate effects of moxifloxacin on LPS-induced ALI in a rat model. MATERIAL AND METHOD: The rats were divided into 3 groups as the control group (C), the LPS insult group (L), and the LPS+moxifloxacin treated group (L-M). ALI was induced by endotracheal instillation of E.coli LPS, then moxifloxacin was given in 30 minutes. Five hours later, we checked the lung weight/body weight ratio(the L/BW ratio), the protein & neutrophils in the bronchoalveolar lavage fluid (BALF), the myeloperoxidase (MPO) activity & the malondialdehyde (MDA) content, the expressions of cytosolic and secretory phospholipase A2 (c, sPLA2), and the morphology of the lung with using a light microscope. RESULT: The L/BW ratio, the protein content and the neutrophil count in the BALF, and the MPO activity and the MDA content in lung were significantly increased in group L compared to group C, and these factors were markedly decreased in group L-M compare to group L. The cPLA2 expression and the sPLA2 expression were increased in group L and the cPLA2 expression was decreased in group L-M. Yet the sPLA2 expression was not changed in group L-M. Morphologically, many inflammatory findings were observed in group L, but not in group L-M. CONCLUSION: Many of the inflammatory changes of ALI that were caused by LPS insult were ameliorated by moxifloxacin treatment.
Palavras-chave
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1
Índice:
WPRIM
Assunto principal:
Quinolinas
/
Síndrome do Desconforto Respiratório
/
Compostos Aza
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Líquido da Lavagem Broncoalveolar
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Peroxidase
/
Sepse
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Citosol
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Fosfolipases A2 Secretórias
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Lesão Pulmonar Aguda
/
Luz
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Ko
Revista:
The Korean Journal of Thoracic and Cardiovascular Surgery
Ano de publicação:
2009
Tipo de documento:
Article