Research progress of trpm7 channel and tumor development / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12): 166-170, 2020.
Artigo
em Chinês
| WPRIM
| ID: wpr-857011
ABSTRACT
Transient receptor potential melastatin-subfamily member 7(TRPM7) is a non-selective cation channel fused with a functional kinase domain. Studies have shown that TRPM7 is aberrantly expressed in tumor cells. TRPM7 plays a variety of functional roles in cancer cells including survival t cell cycle progression, proliferation, invasion, epithelial-mesenchymal transition (EMT) and angiogenesis. The high correlation between TR-PM7 and tumorigcnesis makes TRPM7 a prognostic indicator and a potential therapeutic target for malignant tumors. In this arti cle , we review the research progress of TRPM7 and tumor progression, explore the mechanism of TRPM7-mediated tumor development and the clinical treatment of tumor strategy targeting TRPM7, and provide some reference for follow-up research and clinical treatment.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmacological Bulletin
Ano de publicação:
2020
Tipo de documento:
Artigo
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